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Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Li Shang, Mingrong Wang

Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 401-410 doi: 10.1007/s11684-013-0286-y

Abstract:

Esophageal squamous cell carcinoma (ESCC) is one of the most common types of gastrointestinal cancers

Keywords： esophageal squamous cell carcinoma (ESCC) early detection molecular classification molecular markers

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Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 290-303 doi: 10.1007/s11684-022-0956-8

Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer death worldwide.inhibiting CDK2 activity and affecting downstream phosphorylation of MCM2, c-Myc and Rb, resulting in cell

Keywords： benzydamine cyclin-dependent kinase 2 patient-derived xenograft esophageal squamous cell carcinoma

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Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3, Pages 357-362 doi: 10.1007/s11684-009-0046-1

Abstract: expression of pituitary tumor transforming gene (PTTG) and basic fibroblast growth factor (bFGF) in oral squamouscell carcinoma (OSCC) and tongue cancer cell line Tca8113, as well as their effects on each other.

Keywords： carcinoma squamous cell pituitary tumor transforming gene (PTTG) protein basic fibroblast growth factor

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p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Frontiers of Medicine 2010, Volume 4, Issue 4, Pages 412-418 doi: 10.1007/s11684-010-0260-x

Abstract: mutations have been found in many esophageal squamous cell carcinoma (ESCC) clinical specimens and cellidentified the correlation between p53 functional activation and its genotype in five different ESCC cellTo examine the potential p53 activation in a certain ESCC cell line, DNA damage methods including X-rayinvestigated using Western blot and reverse transcription-polymerase chain reaction (RT-PCR) after cellThe results showed that in KYSE 30 cell line with mutant and KYSE 150 with wild-type , p53 could be

Keywords： p53 esophageal squamous cell carcinoma DNA damage

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Genomic variations in the counterpart normal controls of lung squamous cell carcinomas

Dalin Zhang, Liwei Qu, Bo Zhou, Guizhen Wang, Guangbiao Zhou

Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 280-288 doi: 10.1007/s11684-017-0580-1

Abstract:

Lung squamous cell carcinoma (LUSC) causes approximately 400 000 deaths each year worldwide.study, we sequenced the whole genomes of three normal lung tissue samples and their paired adjacent squamouscell carcinomas.

Keywords： lung cancer counterpart normal control genomic variations

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GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamouscell carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 1, Pages 119-131 doi: 10.1007/s11684-022-0949-7

Abstract: Treating patients with esophageal squamous cell carcinoma (ESCC) is challenging due to the high chemoresistanceGDF15 improved the tolerance of ESCC cell lines to low-dose cisplatin by regulating AKT phosphorylation

Keywords： GDF15 esophageal squamous cell carcinoma chemoresistance cellular metabolism TGFBR2 AKT

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U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 478-486 doi: 10.1007/s11684-015-0420-0

Abstract: telomere length could affect predisposition to multiple cancers, but evidence regarding esophageal squamouscell carcinoma (ESCC) was still uncertain.

Keywords： esophageal squamous cell carcinoma telomere length genetic variants susceptibility genome-wide association

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Bevacizumab in combination with pemetrexed and platinum for elderly patients with advanced non-squamousnon-small-cell lung cancer: a retrospective analysis

Frontiers of Medicine 2022, Volume 16, Issue 4, Pages 610-617 doi: 10.1007/s11684-021-0827-8

Abstract: monoclonal antibody, has significantly improved the clinical outcomes of patients with advanced non-squamous

Keywords： bevacizumab elderly patient advanced non-small-cell lung cancer overall survival toxicity

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Triage for management of cervical high-grade squamous intraepithelial lesion patients with positive margin

Yuya Dou, Xiaodan Zhang, Yang Li, Fenfen Wang, Xing Xie, Xinyu Wang

Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 223-228 doi: 10.1007/s11684-017-0517-8

Abstract:

The objective of this study is to guide a triage for the management of cervical high-grade squamous

Keywords： cervical high-grade squamous intraepithelial lesion conization positive surgical margin hysterectomy

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Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research and a new co-clinical model for treatment optimization

Shuyang Sun,Zhiyuan Zhang

Frontiers of Medicine 2016, Volume 10, Issue 1, Pages 104-110 doi: 10.1007/s11684-016-0432-4

Abstract: bioinformatics have begun to reveal the complex genetic landscape in human cancer genomes, including oral squamouscell carcinoma (OSCC).

Keywords： patient-derived xenograft models personalized medicine co-clinical trial patient stratification oral squamouscell carcinoma

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Clinical response with functional image during radiotherapy of esophageal squamous cell carcinoma

Yu Jinming

Strategic Study of CAE 2012, Volume 14, Issue 7, Pages 9-19

Abstract:

18F-FLT uptake can be used to monitor the biological response of esophageal SCC and normal tissue to RT. Increased uptake of 18F-FLT following treatment interruptions may reflect accelerated repopulation. 18F-FLT PET may have advantages compared to 18F-FDG PET in differentiating inflammation from tumor. 18F-FLT PET may help oncologists predict treatment response as early as one week after the beginning of treatment and estimate clonogenic repopulation during RT. 18F-FETNIM PET can depict hypoxia in esophageal SCC. Prior to CCRT, tumor hypoxia demonstrates spatial variability in different days, though overall 18F-FETNIM uptake remains similar. Baseline SUVmax may be predictive of treatment response.

Keywords： esophageal carcinoma radiotherapy positron emission tomography accelerated repopulation hypoxia

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Microfluidics for cell-cell interactions: A review

Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1, Pages 90-98 doi: 10.1007/s11705-015-1550-2

Abstract: The well-designed microscale intermediary is also ideal for the study of cell biology.Particularly, microfluidic chip is helpful for better understanding cell-cell interactions.

Keywords： microfluidic chip co-culture cell-cell interactions review

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Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Frontiers of Medicine Pages 939-956 doi: 10.1007/s11684-023-0987-9

Abstract: 645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 mice by single-cellMNDCMs having interactions with macrophages and non-proliferative MNDCMs (non-pMNDCMs) with minimal cell–cellThese MNDCMs were mapped to the heart by integrating the spatial and single-cell transcriptomic data.In conclusion, a novel non-pMNDCM subpopulation with minimal cell–cell communications was unveiled, highlighting

Keywords： mononuclear diploid cardiomyocytes cell–cell communication cardiac fibroblast single-cell RNA sequencing

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Deubiquitinases as pivotal regulators of T cell functions

Xiao-Dong Yang, Shao-Cong Sun

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 451-462 doi: 10.1007/s11684-018-0651-y

Abstract: Defect in T cell activation is associated with severe immune deficiencies, whereas aberrant T cell activationAn emerging mechanism that regulates T cell activation and tolerance is ubiquitination, a reversibleIt is now well recognized that DUBs are crucial regulators of T cell responses and serve as potential

Keywords： deubiquitinase ubiquitination T cell activation T cell differentiation T cell tolerance

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Cell surface protein engineering for high-performance whole-cell catalysts

Hajime Nakatani,Katsutoshi Hori

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1, Pages 46-57 doi: 10.1007/s11705-017-1609-3

Abstract: Cell surface protein engineering facilitated by accumulation of information on genome and protein structureinvolves heterologous production and modification of cell surface proteins using genetic engineering, and is important for the development of high-performance whole-cell catalysts.In this field, cell surface display is a major technology by exposing target proteins, such as enzymes, on the cell surface using a carrier protein.

Keywords： cell surface engineering surface display whole-cell catalysts bioprocess

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Title Author Date Type Operation

Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Li Shang, Mingrong Wang

Journal Article

Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Journal Article

Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Journal Article

p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Journal Article

Genomic variations in the counterpart normal controls of lung squamous cell carcinomas

Dalin Zhang, Liwei Qu, Bo Zhou, Guizhen Wang, Guangbiao Zhou

Journal Article

GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamouscell carcinoma

Journal Article

U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Journal Article

Bevacizumab in combination with pemetrexed and platinum for elderly patients with advanced non-squamousnon-small-cell lung cancer: a retrospective analysis

Journal Article

Triage for management of cervical high-grade squamous intraepithelial lesion patients with positive margin

Yuya Dou, Xiaodan Zhang, Yang Li, Fenfen Wang, Xing Xie, Xinyu Wang

Journal Article

Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research and a new co-clinical model for treatment optimization

Shuyang Sun,Zhiyuan Zhang

Journal Article

Clinical response with functional image during radiotherapy of esophageal squamous cell carcinoma

Yu Jinming

Journal Article

Microfluidics for cell-cell interactions: A review

Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng

Journal Article

Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Journal Article

Deubiquitinases as pivotal regulators of T cell functions

Xiao-Dong Yang, Shao-Cong Sun